PREMIUM’s results disseminated through the publication in scientific journals are presented here below.



Content and link with WP, tasks


Fonseca, F., Pénicaud, C. Tymczyszyn, E.E., Gomez-Zavaglia, A., Passot, S. 2019. Factors influencing the membrane fluidity and the impact on production of lactic acid bacteria starters. Applied Microbiology and Biotechnology 103(17):6867–6883.


Invited mini-review on the state of the current understanding of stabilization mechanisms related to membrane properties, therefore in full in WP4 and also the link of membrane properties and particularly membrane fluidity to the production conditions (also related to WP3). WP4, WP3


Martins, G.N., Ureta, M.M., Tymczyszyn, E.E., Castilho, P.C.,  Gómez-Zavaglia, A. 2019. Technological Aspects of the Production of Fructo and Galacto-Oligosaccharides. Enzymatic Synthesis and Hydrolysis. Frontiers in Nutrition 6:78.


Invited review about the state of the art of the production of FOS and GOS, by synthesis and hydrolysis. WP2


Meneghel, J., Kilbride, P., Morris, J.G., Fonseca, F. 2019. Physical events occurring during the cryopreservation of immortalized human T cells. PLoS ONE 14(5): e0217304.

Asymptote, INRA

Article reporting on the intracellular glass transition temperature of Jurkat cells (an immortalized human T cell line) by DSC. This provides i) a better understanding of the behavior of mammalian cells during freezing and ii) is essential for optimizing cryopreservation protocols of mammalian cells. Such optimized protocols being used within WP5 when screening FOS/GOS as new cryoprotectants for mammalian cells. WP4, WP5


Girardeau, A., Puentes, C., Keravec, S., Peteuil, P., Tréléa, C., Fonseca, F. 2019. Influence of culture conditions on the technological properties of Carnobacterium maltaromaticum CNCM I-3298 starters. Journal of Applied Microbiology, 126: 1468-1479.

INRA, APT, Cryolog

Article reporting on the mapping of Carnobacterium maltaromaticum physiological states in pilot production conditions. This study was necessary for identifying relevant production conditions for studying preservation processes in WP3 and preservations mechanisms in WP4. WP3, WP4


Ghibaudo, F., Gerbino, E., Hugo, A., Simões, M.G., Alves, P., Costa, B., Campodall´Orto, V., Gómez-Zavaglia, A., Simões, P.N. 2018. Development and characterization of iron-pectin beads as a novel system for iron delivery to intestinal cells. Colloids and Surfaces B: Biointerfaces 170: 538-543.


Article related with the physical characterization of encapsulating materials. WP2, WP3


Romano, N., Araujo-Andrade, C., Lecot, C., Mobili, P., Gómez-Zavaglia, A. 2018. Infrared spectroscopy as an alternative methodology to evaluate the effect of structural features on the physical-chemical properties of inulins. Food Research International, 109(2018): 223–231.


Article that involves the physical and chemical properties determination of amorphous and crystalline inulins (raw polysaccharide used to obtain FOS by hydrolysis), using WAXS, DSC, FTIR and multivariate analysis. WP2


Simões, M.G., Hugo, A., Alves, P., Pérez, P.F., Gómez-Zavaglia, A., Simões, P.N. 2018. Long term stability and interaction with epithelial cells of freeze-dried pH-responsive liposomes functionalized with cholesterol-poly(acrylic acid). Colloids and Surfaces B-Biointerfaces, 164: 50-57.


Article related with experimental set up of methods included in PREMIUM (leakage experiments, work with eukaryotic cells). WP4

In this folder

Article's figure
Recently published review article in the journal Applied Microbiology and Biotechnology on the functionalities, applications and production stages of L. salivarius

Modification date : 03 July 2023 | Publication date : 08 February 2018 | Redactor : CP